+86-531-88916568
hydroxypropyl beta cyclodextrin
Home » Cyclodextrin » Cyclodextrin derivatives » hydroxypropyl beta cyclodextrin
Share to:

hydroxypropyl beta cyclodextrin

When classical solubilization or stabilization methods are not helpful, cyclodextrin derivatives such as hydroxypropyl beta cyclodextrin should be considered first
  • HPBCD
  • 128446-35-5

Hydroxypropyl betacyclodextrin                                 TDS-(2-Hydroxypropyl)-beta-cyclodextrin.pdf

Abbreviation

HPBCD

CAS No:

128446-35-5

Synonym:

Hydroxypropyl-beta-cyclodextrin,Hydroxypropyl-β-cyclodextrin,(2-Hydroxypropyl)-beta-cyclodextrin

Molecular formula:

C42H70-nO35(C3H8O2)n

Standard:

Enterprise standard

Quality:

Technical grade

Characteristics 

1. Increase the solubility of the drug.            

Bioactive macromolecules with poor water solubility and stability are constantly emerging in modern pharmacy. Hydroxypropyl beta cyclodextrin can solubilize the drug in water and avoid the use of organic solvents, surfactants and lipids. It can solubilize drugs, reduce irritation, improve stability and make them suitable for injection. The solubilization ability of hydroxypropyl beta cyclodextrin is 200 times higher than that of beta cyclodextrin.     

2. Improve drug stability            

The stability of the drug can be improved by inclusion of the guest molecules with hydroxypropyl beta cyclodextrin, but there are also some rules: 1) the stability of the inclusion complexes with different host guest ratios is different, for example, the stability of the inclusion complexes formed by hydroxypropyl beta cyclodextrin and pilocarpine nitrate is better when the host guest ratio is 1:1 or 1:2. 2) The inclusion complex formed at low temperature is more stable than that formed at high temperature.          

3. Promote drug absorption, reduce the stimulation of drugs to the body.            

Hydroxypropyl beta cyclodextrin can improve the absorption of drugs from nasal cavity, rectum, eye mucosa and skin.           

4. As a carrier of sustained-release and targeted preparations.            

Hydroxypropyl beta cyclodextrin can make lipophilic drugs reach brain and lipid rich organs, and increase the concentration of drugs in target organs.            

5. Improve the bioavailability of drugs            

Hydroxypropyl beta cyclodextrin can be used to increase the solubility and stability of many water-insoluble, volatile or unstable drugs. The drug released quickly in vivo after inclusion, which can greatly improve the bioavailability of the drug.


Specification

Please find attached TDS.

 

Package:

Normal package:10kg/fiber drum

 

Storage:

Preserve in well-closed containers,Store at room temperature.


Product Inquiry

PRODUCT CATEGORY

QUICK LINKS

CONTACT INFORMATION

Tel: +86-531-88916568
 Mail: enquiry@cydextrin.com
​​​​​​​ Address: Boxing Economic Development Zone, Binzhou, Shandong, China.

FREE CONSULTATION

Contact us
© 2020 Shandong Binzhou Zhiyuan Biotechnology Co., Ltd. All rights reserved. Sitemap