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What dosage form is betadex sulfobutyl ether sodium used to make?
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What dosage form is betadex sulfobutyl ether sodium used to make?

Views:0     Author:Site Editor     Publish Time: 2021-06-30      Origin:Site

Compared with traditional CD, pharm grade cyclodextrins has better water solubility. Injection grade betadex sulfobutyl ether sodium has low hemolysis and low nephrotoxicity, and is a new type of pharmaceutical excipient with very broad application prospects. Therefore, CAS No. 182410-00-0 is widely used to make various dosage forms of drugs.


Here is the content list:

  • What are functions of betadex sulfobutyl ether sodium?

  • What dosage forms can betadex sulfobutyl ether sodium produce?

  • What are factors affecting formation of betadex sulfobutyl ether sodium clathrate?


What are functions of betadex sulfobutyl ether sodium?

Betadex sulfobutyl ether sodium is a sulfonated modified compound of pharm grade cyclodextrins, which is an anionic CD derivative with high water solubility.

It can be well included with drug molecules to become a non-covalent complex, thereby improving the stability of the drug. Betadex sulfobutyl ether sodium can also increase the water solubility of the drug, reduce nephrotoxicity, ease the hemolysis of the drug, control the release rate of the drug, and cover up bad odors.

  • Solubilization

Neutral, positive and negative APIs can be effectively combined with betadex sulfobutyl ether sodium. It can increase the solubility of different compounds in medicine by many times.

  • Biocompatibility

CAS No. 182410-00-0 has good biocompatibility and can be administered by injection, oral, eye, nose, topical and inhalation.

  • Stability

The interaction between the drug and betadex sulfobutyl ether sodium is important. The lipophilic cavity provides a beneficial protective environment for the API, while the hydrophilic surface provides excellent water solubility and stability.


What dosage forms can betadex sulfobutyl ether sodium produce?

Betadex sulfobutyl ether sodium has good solubility in water and can improve the solubility of poorly soluble drugs. In some cases, the dissolved betadex sulfobutyl ether sodium has an enzyme-like catalysis and is suitable as an auxiliary agent for injections to catalyze the reaction of drugs or other ingredients in the prescription.

If the solid preparation contains a complex or mixture of the drug and pharm grade cyclodextrins, many problems will occur during the preparation and storage of the finished product. For example, the water added during the production process may cause unnecessary side reactions.

The inclusion compound is likely to decompose again in water and become free drugs and pharm grade cyclodextrins. CD dissolved in water is a good catalyst, even if it is only a small amount, it can greatly catalyze the reaction.

Therefore, dry granulation and direct powder compression are the preferred methods in the preparation of pharmaceutical products containing betadex sulfobutyl ether sodium. If the formulation does not contain water, the solid formulation containing the inclusion compound is still very stable.

In addition, betadex sulfobutyl ether sodium takes effect very quickly intravenously. Subcutaneous and intradermal administration can be quick-acting or slow-acting, depending on the nature of the prescription. 

Compared with drugs in oily preparations, betadex sulfobutyl ether sodium in aqueous solutions is absorbed more quickly than in high schools, but suspended drugs are absorbed more slowly than dissolved drugs.


What are factors affecting formation of betadex sulfobutyl ether sodium clathrate?

Regardless of the dosage form of betadex sulfobutyl ether sodium, it is necessary to form clathrates to assist drugs, and whether the clathrates can be formed smoothly is affected by many factors. One of the most important is the choice of feed ratio.

In the production of betadex sulfobutyl ether sodium, different ratios of host and guest molecules should be used for inclusion, and the content and yield of different inclusion compounds should be analyzed to calculate the dosage ratio that should be selected.

Secondly, producers of betadex sulfobutyl ether sodium have to choose production processes based on equipment conditions. Different production methods of betadex sulfobutyl ether sodium have their own advantages and disadvantages.

The saturated aqueous solution method is more commonly used, feed ratio should be paid attention to during the grinding method, and the ultrasonic method saves time and has a higher yield. 

In addition, the size of the dispersion force, stirring rate and time, drying method and other factors will also affect the formation of betadex sulfobutyl ether sodium inclusion compound. 

The various factors of the inclusion conditions can be designed with orthogonal design, and the volatile oil yield, utilization rate, and oil content are investigated as indicators.


The producer of betadex sulfobutyl ether sodium should also conduct a comprehensive evaluation of the extraction process, select the best process through comprehensive analysis. As a professional pharm grade cyclodextrins manufacturer, Shandong Binzhou Zhiyuan Biotechnology Co., Ltd. has undergone multiple tests on our products to ensure quality. If you want stable and safe CAS No. 182410-00-0, please contact our customer service.


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