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What are the physical and chemical properties of betadex sulfobutyl ether sodium?
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What are the physical and chemical properties of betadex sulfobutyl ether sodium?

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Drugs that are easily oxidized and hydrolyzed are protected from light, oxygen, heat and other factors due to the inclusion of SBE-β-CD. Therefore, medical grade betadex sulfobutyl ether sodium can extend the potency and shelf life of the drug. In particular, CAS No. 182410-00-0 has special affinity and inclusion properties for nitrogen-containing drugs.


Here is the content list:

  • What is application background of betadex sulfobutyl ether sodium?

  • What are the physical and chemical properties of SBE-β-CD?

  • Which preparations can betadex sulfobutyl ether sodium be used in?


What is application background of betadex sulfobutyl ether sodium?

There are abundant domestic starch resources. Betadex sulfobutyl ether sodium is an important product of starch deep processing, which is produced by the action of cyclodextrin glycosyltransferase on starch.

β pharm grade cyclodextrins has a moderate cavity size, stable properties, low production cost, and the widest application range. However, due to its easy formation of intramolecular hydrogen bonds, low solubility at room temperature, relatively limited hydrophobic region and catalytic activity, and studies have shown that β-CD has potential hemolytic effects and non-digestive tract safety, its application is limited.

At present, the industry often adopts chemical or enzymatic modification methods to graft specific substituents onto cyclodextrin molecules to increase their hydrophilicity, reduce or eliminate their hemolysis and nephrotoxicity. SBE-β-CD is an important product of modified cyclodextrin.

From the structural point of view, betadex sulfobutyl ether sodium has a rigid three-dimensional cavity cyclic oligosaccharide, which is hydrophobic inside and hydrophilic outside, so it has good embedding characteristics.

Due to the particularity of the molecular structure, betadex sulfobutyl ether sodium has a special effect no matter in theoretical research or practical application, especially in medicine.


What are the physical and chemical properties of SBE-β-CD?

Betadex sulfobutyl ether sodium is a white or almost white amorphous solid powder with a solubility greater than 700 mg/mL in water. The pH of 30% betadex sulfobutyl ether sodium aqueous solution is 5.4~6.8.

After oral administration, betadex sulfobutyl ether sodium is rapidly excreted in urine as a prototype, and its clearance rate is close to the glomerular filtration rate. 

It is mainly distributed in the extracellular fluid and has a low binding rate to plasma proteins. At the same concentration, the hemolytic effect of SBE-β-CD is far less than that of β-CD, and it has low nephrotoxicity and less irritation.


Which preparations can betadex sulfobutyl ether sodium be used in?

As a new type of pharmaceutical excipient, betadex sulfobutyl ether sodium has the unparalleled advantages of other CD derivatives. SBE-β-CD is negatively charged and has a special affinity with positively charged drugs.

Therefore, betadex sulfobutyl ether sodium can better increase the solubility of the drug and improve the bioavailability of the drug. At present, it has good applications in oral preparations, injections, nasal preparations, ophthalmic preparations, transdermal preparations and so on.

Oral drugs

Poor solubility is one of the main reasons for the low oral bioavailability of poorly soluble drugs. Betadex sulfobutyl ether sodium can be used as an inclusion material to form clathrates with poorly soluble drugs, thereby improving the solubility of poorly soluble drugs and helping to increase oral bioavailability.

In addition, betadex sulfobutyl ether sodium also has the characteristics of increasing the stability of the drug, reducing the irritation of the drug, and masking the unpleasant smell of the drug.

Injection

Betadex sulfobutyl ether sodium can not only increase the solubility of the drug, improve the stability and safety of the drug, but also reduce the irritation of the injection to the administration site, so that the drug can quickly reach the required blood concentration and prolong the action time of the drug.

Nasal administration

Rapid drug absorption and onset of action, high bioavailability, and avoidance of first pass effect of the liver are features of nasal administration. It has become one of the hotspots of pharmaceutics research.

Betadex sulfobutyl ether sodium used in nasal preparations can improve the solubility and stability of the drug, increase the permeability of the nasal mucosa, and help improve the bioavailability of the drug.

Eye medicine

The bioavailability of most drugs in the eyes is low, mainly due to the rapid and large loss of pre-corneal drugs due to drainage and tear dilution and flushing.

The inclusion of betadex sulfobutyl ether sodium with irritating drugs can mask its irritation, increase the corneal permeability of the drug, improve bioavailability, and can also replace excipients that are irritating to eye tissue.

Transdermal preparations

Betadex sulfobutyl ether sodium is used in transdermal preparations to increase the transdermal permeability of the drug, thereby increasing the bioavailability, improving the solubility and stability of the drug, preventing the loss of volatile components, and masking bad odors.


Although betadex sulfobutyl ether sodium can be used in the production of many dosage forms of drugs, it may also have the disadvantage of reducing the effectiveness of the drug while increasing the solubility and stability of the drug. Therefore, Shandong Binzhou Zhiyuan Biotechnology Co., Ltd. recommends that drug manufacturers be cautious in the use of betadex sulfobutyl ether sodium. If you have any questions about the use of betadex sulfobutyl ether sodium, you can consult us.


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