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What are the effects of reaction conditions on the degree of substitution of hydroxypropyl beta-cyclodextrin
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What are the effects of reaction conditions on the degree of substitution of hydroxypropyl beta-cyclodextrin

Views:0     Author:Site Editor     Publish Time: 2021-06-24      Origin:Site

       Hydroxypropyl beta cyclodextrin has good solubilization and solubilization effects, can increase bioavailability, control and slow release, and reduce irritation to the human body, so it has a very broad application prospect in the fields of pharmacy and chiral separation.


       We obtained the law of the influence of reaction conditions on the average degree of substitution by using the response surface analysis method.


Experimental results show:


1. The concentration of alkali has a greater impact on the average degree of substitution of the product and the substitution position of the hydroxypropyl group. The average degree of substitution of the product will gradually increase as the alkali concentration increases. When the alkali concentration is low, it is very easy to produce 2-hydroxypropyl-β-cyclodextrin substituted at the 2-position. When the alkali concentration is high, it is easy to produce 2-hydroxypropyl-β-substituted at the 6-position. Cyclodextrin;


2. The concentration of propylene oxide in the raw material has a relatively large impact on the average degree of substitution of the product and the substitution position of the hydroxypropyl group. As the molar ratio of propylene oxide to β-cyclodextrin in the raw material increases, the average degree of substitution of the product will also increase. When propylene oxide:β-cyclodextrin is between 10:1 and 12:1, the average degree of substitution of the product will increase slowly.


  Hydroxypropyl beta-cyclodextrin under different alkali concentration environment, the time required to complete the reaction is also different. When the alkali concentration is relatively low, the reaction will basically end after 24 hours, and when the alkali concentration is relatively high, it will take at least 72 hours to complete the reaction.


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