Views:0 Author:Site Editor Publish Time: 2021-05-11 Origin:Site
Loratadine is a second-generation H2 receptor antagonist. It is a potent and long-acting tricyclic antihistamine. It is mainly used clinically to treat allergic rhinitis, seasonal rhinitis, skin allergies, and nettle Disease and allergic asthma. The custom-made loratadine on the market in China all have slow absorption and low bioavailability due to the fact that loratadine is a fat-soluble drug insoluble in water.
In recent years, cyclodextrin has become the most widely used inclusion material for poorly soluble drugs. In particular, the inclusion of hydrophilic hydroxypropyl beta-cyclodextrin and poorly soluble drugs can improve the solubility, dissolution rate and biological characteristics of the drug. Utilization. According to experimental studies, when the pH of hydroxypropyl beta-cyclodextrin is 3.5, the solubility of loratadine is the largest. But when the pH is 5.5 and 6.5, the drug is mainly incorporated into the hydroxypropyl beta-cyclodextrin in molecular form, and the drug is relatively stable at this time, so the oil-water distribution coefficient of the drug at this time is greater than the pH of 4.5 However, the concentration of the included drug is still greater than the concentration when the pH is 4.5.