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The solubilization effect of hydroxypropyl beta-cyclodextrin on ellagic acid
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The solubilization effect of hydroxypropyl beta-cyclodextrin on ellagic acid

Views:0     Author:Site Editor     Publish Time: 2021-03-29      Origin:Site

       Ellagic acid is a dimeric derivative of gallic acid, a natural polyphenol compound, widely present in pomegranate, raspberry, strawberry, blackberry, walnut, wolfberry and other soft fruit and nut plants. In addition, ellagic acid can also prevent and treat inflammation, diabetic complications, hypertension, asthma and other positive diseases. Its antioxidant and whitening effects are also commonly used in cosmetics, but its solubility is greatly improved. Limits its use.


       Cyclodextrin has a "hydrophobic inside and hydrophilic outside" cavity structure, so it is often used as an inclusion material. Inclusion technology, in short, is to encapsulate a molecule in the cavity structure of another molecule to form an inclusion compound, which is often used in the preparation of drugs. The clathrate formed can improve the solubility of the drug, powder the liquid drug and prevent volatilization, adjust the drug release rate to improve the bioavailability of the drug, mask the special smell of the drug, and increase the stability of the drug. When hydroxypropyl beta-cyclodextrin is used to clathrate ellagic acid, its superoxide anion free radical scavenging ability is the best, and the solubility of the clathrate compound is also increased by 102%. The results are better than those of monomer ellagic acid. It shows that the inclusion effect can improve the solubility and antioxidant properties of ellagic acid.


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       Shandong Binzhou Zhiyuan Biotechnology Co., Ltd. has been producing hydroxypropyl beta-cyclodextrin for more than ten years, and this product has obtained CDE registration number: F20209990366. Customers who are interested in knowing can call for details, +86 531 88976568.


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