Study on the solubilization of pranoprofen by methyl-β-cyclodextrin by fluorescence spectroscopy

Beta-cyclodextrin derivatives solubilize drug molecules can significantly improve the physical and chemical properties of drugs, can solve many difficulties encountered in drug production, and provide an effective means for the development of new drug preparations and new dosage forms. 

Fluorescence spectroscopy can characterize the molecules. The interaction between the two, while being able to detect the concentration of drug molecules in a larger range. The fluorescence spectrum and phase solubility diagram of Pranoprofen (PRA) in methyl-β-cyclodextrin (Me-beta-CD) solution were measured. The results show that methyl-β-cyclodextrin and Pranoprofen form a 1:1 inclusion complex, which belongs to the AL type.

The enveloping equilibrium constant is 2.0665l/mol, and in the 45mmol/L methyl-β-cyclodextrin solution, the solubility of pranoprofen increases 42 times to 2.22mg/mL. At the same time, computer simulations show that the aromatic ring end of Pranoprofen is inclined into the cavity of Me-beta-CD from a large mouth.