Views: 0 Author: Site Editor Publish Time: 2022-06-21 Origin: Site
Ellagic acid is a dimerized derivative of gallic acid, a natural polyphenolic compound, widely found in pomegranate, raspberry, strawberry, blackberry, walnut, wolfberry and other soft fruit and nut plants. In addition, ellagic acid can also prevent and treat positive diseases such as inflammation, diabetic complications, hypertension and asthma. Its antioxidant properties and whitening effects are also commonly used in cosmetics, but its solubility is greatly increased. restricted its use.
Cyclodextrin has a cavity structure of "inner hydrophobicity and outer hydrophilicity", so it is often used as an inclusion material. Inclusion technology, in short, is to encapsulate a molecule in the cavity structure of another molecule to form an inclusion complex, which is often used in the preparation of drugs. The formed inclusion compound can improve the solubility of the drug, powder the liquid drug and prevent volatilization, adjust the drug release rate to improve the bioavailability of the drug, mask the special smell of the drug and increase the stability of the drug. When using hydroxypropyl betacyclodextrin to include ellagic acid, its superoxide anion free radical scavenging ability is the best, and the solubility of the inclusion complex is also increased by 102%. The results are better than monomer ellagic acid. It shows that the inclusion effect can improve the solubility and antioxidant activity of ellagic acid.
Shandong Binzhou Zhiyuan Biotechnology Co., Ltd. has been producing hydroxypropyl betacyclodextrin for more than ten years, and the product has obtained DMF registration.