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Solubilization of Albendazole by Hydroxypropyl Beta-Cyclodextrin
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Solubilization of Albendazole by Hydroxypropyl Beta-Cyclodextrin

Views:0     Author:Site Editor     Publish Time: 2021-06-11      Origin:Site

      Albendazole (ABZ) is a kind of benzimidazole derivatives with wide anthelmintic spectrum, strong effect and high safety. Since its market, it has been widely used in the treatment of pinworms, roundworms, tapeworms and other parasites. Infection is the first deworming drug recommended by the World Health Organization. However, ABZ has strong fat solubility, poor intestinal absorption, low plasma concentration, and poor bioavailability. Clinically, the common dosage form of ABZ has a low cure rate for non-intestinal parasitic diseases (about 30%), and the curative effect of ABZ is positive with its solubility. Related.


HPBCD, HYDROXYPROPYL


       Hydroxypropyl beta cyclodextrin has a hollow structure, which can include ABZ and play a solubilizing effect. The inclusion process of ABZ entering the cyclodextrin cavity structure is an endothermic process, but due to the small value, the temperature increase is still unfavorable to the inclusion process. The solubilization effect of hydroxypropyl beta-cyclodextrin decreases with the increase of temperature. When the solubilization temperature is 25℃, its solubilization effect is the best.


       Shandong Binzhou Zhiyuan Biotechnology Co., Ltd. has been producing hydroxypropyl beta-cyclodextrin for more than ten years, and this product has obtained CDE registration number: F20209990366. Customers who are interested in purchasing products are welcome to call for detailed inquiry, +86-531-88916568.


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