Views:0 Author:Site Editor Publish Time: 2021-07-01 Origin:Site
Glycyrrhizin (GLA) is a hydrophobic isoflavone compound, a unique component of Glycyrrhiza glabra, and has a wide range of biological activities, such as prevention of atherosclerosis, anti-inflammatory, anti-osteoporosis, and neuroprotective effects. It is worth noting that GLA can inhibit the activity of tyrosinase and hinder the production of melanin in the skin. It is called "whitening gold" in the cosmetics field. However, GLA is almost insoluble in water, which limits its application in topical preparations.
After the drug is included in cyclodextrin, and then absorbed through the skin in vitro, the cumulative permeation of the drug is significantly increased. Among them, hydroxypropyl beta-cyclodextrin (HP-β-CD) can improve the solubility of insoluble substances, and at the same time It is beneficial to improve the stability of the inclusion compound.
The hydroxypropyl beta cyclodextrin produced by Shandong Binzhou Zhiyuan Biology has an effect on the properties, preparation process, stability, pharmacology, toxicology, teratogenicity, mutagenicity, carcinogenesis, and hemolysis of hydroxypropyl beta cyclodextrin. In terms of irritation and other aspects, more in-depth research has been done. The prepared inclusion compound can significantly improve the stability of the drug, increase the solubility and bioavailability of the insoluble drug, reduce the side effects of the drug, and mask the unpleasant smell of the drug.