Views:0 Author:Site Editor Publish Time: 2021-07-22 Origin:Site
Methyl-β-cyclodextrin is widely used to increase the permeability of cells, thereby increasing the absorption of small molecules such as glucose and nanoparticles.
Cyclodextrins are a family of cyclic oligosaccharides with a hydrophilic outer surface and a lipophilic central cavity. Cyclodextrin molecules are relatively large and have many hydrogen donors and acceptors, so in general, they do not penetrate lipophilic membranes. In the pharmaceutical industry, cyclodextrin is mainly used as a complexing agent to increase the water solubility of poorly soluble drugs and improve their bioavailability and stability. Cyclodextrin has many uses in medical applications, including improving the bioavailability of drugs.
Methyl-β-cyclodextrin rapidly induces apoptosis of PEL cells by lowering cell membrane cholesterol. Methyl-β-cyclodextrin inhibited the growth of PEL cell lines in a dose-dependent manner. The IC50 of each cell line is 3.33-4.23mm.
Methyl-β-cyclodextrin is a highly water-soluble cyclic heptanosan composed of β-pyranose units. Among various cholesterol-consuming agents, it has been reported as an effective cholesterol-consuming agent.
Methyl-β-cyclodextrin (Methyl-beta-cyclodextrin) is a water-soluble cycloheptose that has a solubilizing effect on non-polar substances and is widely used in the release of hydrophobic drugs. Methyl-beta-cyclodextrin is also widely used as a cholesterol-lowering agent. Methyl-β-cyclodextrin can significantly reduce clathrin-dependent endocytosis.