Views:0 Author:Site Editor Publish Time: 2021-07-20 Origin:Site
Cyclodextrin (CD) is a kind of cyclic polysaccharide connected by α-1,4-glycosidic bonds. The cyclodextrin family mainly includes α-cyclodextrin, β-cyclodextrin, and γ-cyclodextrin, which are composed of 6, 7, and 8 glucose structural units, respectively, arranged in a truncated cone shape. Among them, the ones connected to the primary carbon The hydroxyl groups are distributed on the top of the truncated cone and the hydroxyl groups connected to the secondary carbon are on the bottom surface of the truncated cone. In the molecular structure of cyclodextrin, the hydroxyl groups of the glucose unit are located outside the truncated cone structure, so the periphery of the truncated cone is hydrophilic, while the inner circle The cavity is hydrophobic. By filling all or part of the hydrophobic molecules into the hydrophobic cavity, cyclodextrin can form inclusion compounds with many hydrophobic drugs, thereby improving the water solubility of the hydrophobic drugs. When the guest molecule is included in the hydrophobic cavity of cyclodextrin, the physical and chemical properties of the guest molecule will change. The changes in the physical and chemical properties of the guest molecule before and after the inclusion can provide an effective characterization method for confirming whether the inclusion compound is formed.
Folic acid is an indispensable water-soluble vitamin for the human body. Studies have shown that folic acid plays an important role in reducing the risk of fetal cardiovascular and cerebrovascular defects and cleft lip risk. However, the solubility of folic acid in water is very small, and the solubility in water at room temperature is only 1.6×10-3mg/ml. The hydrophilic hydroxypropyl beta-cyclodextrin produced by Shandong Binzhou Zhiyuan Bio can improve the solubility of hydrophobic drugs, thereby increasing the absorption rate of hydrophobic drugs through biological barriers. By forming an inclusion compound with hydroxypropyl beta-cyclodextrin, the solubility of folic acid in water is significantly improved. In 1g of the inclusion compound, folic acid can reach 7.7mg, and the solubility of folic acid at room temperature is 1.6×10-3mg/ml In comparison, the solubility is significantly improved. For more information, please inquire: Shandong Binzhou Zhiyuan Biotechnology Co., Ltd. (Hydroxypropyl beta cyclodextrin, sodium sulfobutyl beta cyclodextrin, methyl beta cyclodextrin).