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Injectrion grade Hydroxyproypl betadex
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Injectrion grade Hydroxyproypl betadex

  • HPBCD
  • 128446-35-5

Hydroxypropyl betadex         

Abbreviation

HPBCD

CAS No:

128446-35-5

Synonym:

Hydroxypropyl-beta-cyclodextrin,Hydroxypropyl-β-cyclodextrin,(2-Hydroxypropyl)-beta-cyclodextrin

Molecular formula:

C42H70-nO35(C3H8O2)n

Standard:

USP43-NF38

Quality:

Technical grade


Characteristics 

1. Increase the solubility of the drug.            

 Hydroxypropyl betadex can solubilize the drug in water and avoid the use of organic solvents, surfactants and lipids. It can solubilize drugs, reduce irritation, improve stability and make them suitable for injection.  

2. Improve drug stability            

The stability of the drug can be improved by inclusion of the guest molecules with hydroxypropyl betaex.

3. Promote drug absorption, reduce the stimulation of drugs to the body          

Hydroxypropyl betadex can improve the absorption of drugs from nasal cavity, rectum, eye mucosa and skin.           

4. As a carrier of sustained-release and targeted preparations.            

Hydroxypropyl betadex can make lipophilic drugs reach brain and lipid rich organs, and increase the concentration of drugs in target organs.            

5. Improve the bioavailability of drugs            

 The drug released quickly in vivo after inclusion, which can greatly improve the bioavailability of the drug.


Specification

Appearance:

White or almost white, amorphous or crystalline powder

 

Solubility:

 

Freely soluble in water and in propylene glycol

 

 

Identification:

 

IR:

Same absoprtion bands as USP

(2-Hydroxypropyl)-beta-cyclodextrin RS


Clarity of Solution:

Positive

Molar Substitution

0.4~1.5

Beta Cyclodextrin

≤1.5%

Propylene Glycol

≤2.5%

Total impurities (excluding beta cyclodextrin and

propylene Glycol)

 

≤1.0%

Propylene Oxide

≤1ppm

Loss on drying

≤10.0%

 

Clarity of Solution

1.0g/2ml

1.0g/2ml water solution is clear and transparent

Conductivity

≤200μS/cm

 

Bacterial Endotoxins Test

 

According to preparation needs

 

The total aerobic microbial count

 

≤1000cfu/g

The total combined moulds and yeasts count

≤100cfu/g

 

Package:

Normal package:10kg/fiber drum,20kg/fiber drum

 

Storage:

Preserve in well-closed containers,Store at room temperature.


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