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Abbreviation | HPBCD |
CAS No: | 128446-35-5 |
Synonym: | Hydroxypropyl-beta-cyclodextrin,Hydroxypropyl-β-cyclodextrin,(2-Hydroxypropyl)-beta-cyclodextrin |
Molecular formula: | C42H70-nO35(C3H8O2)n |
Standard: | Enterprise standard |
Quality: | Technical grade |
1. Increase the water solubility of insoluble drugs
Due to the high solubility of 2-Hydroxypropyl-β-cyclodextrin, the water solubility of insoluble drugs can be significantly increased after being enveloped by 2-Hydroxypropyl-β-cyclodextrin.Therefore, it is an ideal solubilizer for insoluble drugs.
2. Increase drug stability
Injection grade 2-Hydroxypropyl-β-cyclodextrin can improve the stability of the preparation drugs. For example, when estradiol is encapsulated with 2-Hydroxypropyl-β-cyclodextrinand placed at room temperature, the half-life of degradation is extended from 1.2 years to 4 years.
3. Reduce the side effects of drugs
Injection grade 2-Hydroxypropyl-β-cyclodextrin can effectively reduce the side effects of preparation drugs.. For example, nimodipine, a vasodilator, is insoluble in water and is easily affected by the first pass effect of the liver when taken orally. 0.05 mol / L hydroxypropyl-b-cyclodextrin can increase its solubility by 60 times and reduce its irritation to muscle. Injection grade 2-Hydroxypropyl-β-cyclodextrin can also relieve the injection pain caused by etomidate.
Please find attached TDS.
Normal package:10kg/fiber drum
Preserve in well-closed containers,Store at room temperature.
Abbreviation | HPBCD |
CAS No: | 128446-35-5 |
Synonym: | Hydroxypropyl-beta-cyclodextrin,Hydroxypropyl-β-cyclodextrin,(2-Hydroxypropyl)-beta-cyclodextrin |
Molecular formula: | C42H70-nO35(C3H8O2)n |
Standard: | Enterprise standard |
Quality: | Technical grade |
1. Increase the water solubility of insoluble drugs
Due to the high solubility of 2-Hydroxypropyl-β-cyclodextrin, the water solubility of insoluble drugs can be significantly increased after being enveloped by 2-Hydroxypropyl-β-cyclodextrin.Therefore, it is an ideal solubilizer for insoluble drugs.
2. Increase drug stability
Injection grade 2-Hydroxypropyl-β-cyclodextrin can improve the stability of the preparation drugs. For example, when estradiol is encapsulated with 2-Hydroxypropyl-β-cyclodextrinand placed at room temperature, the half-life of degradation is extended from 1.2 years to 4 years.
3. Reduce the side effects of drugs
Injection grade 2-Hydroxypropyl-β-cyclodextrin can effectively reduce the side effects of preparation drugs.. For example, nimodipine, a vasodilator, is insoluble in water and is easily affected by the first pass effect of the liver when taken orally. 0.05 mol / L hydroxypropyl-b-cyclodextrin can increase its solubility by 60 times and reduce its irritation to muscle. Injection grade 2-Hydroxypropyl-β-cyclodextrin can also relieve the injection pain caused by etomidate.
Please find attached TDS.
Normal package:10kg/fiber drum
Preserve in well-closed containers,Store at room temperature.