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Injection grade 2-Hydroxypropyl-β-cyclodextrin
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Injection grade 2-Hydroxypropyl-β-cyclodextrin

2-Hydroxypropyl-β-cyclodextrin (HPBCD) is a hydrophilic derivative of B-CD condensed with 1, 2- propylene oxide.
  • HPBCD
  • 128446-35-5

Injection grade 2-Hydroxypropyl-β-cyclodextrin                                 TDS-(2-Hydroxypropyl)-beta-cyclodextrin.pdf

Abbreviation

HPBCD

CAS No:

128446-35-5

Synonym:

Hydroxypropyl-beta-cyclodextrin,Hydroxypropyl-β-cyclodextrin,(2-Hydroxypropyl)-beta-cyclodextrin

Molecular formula:

C42H70-nO35(C3H8O2)n

Standard:

Enterprise standard

Quality:

Technical grade

Characteristics 

1. Increase the water solubility of insoluble drugs            

Due to the high solubility of 2-Hydroxypropyl-β-cyclodextrin, the water solubility of insoluble drugs can be significantly increased after being enveloped by 2-Hydroxypropyl-β-cyclodextrin.Therefore, it is an ideal solubilizer for insoluble drugs.           

 2. Increase drug stability          

Injection grade 2-Hydroxypropyl-β-cyclodextrin can improve the stability of the preparation drugs. For example, when estradiol is encapsulated with 2-Hydroxypropyl-β-cyclodextrinand placed at room temperature, the half-life of degradation is extended from 1.2 years to 4 years.            

3. Reduce the side effects of drugs            

Injection grade 2-Hydroxypropyl-β-cyclodextrin can effectively reduce the side effects of preparation drugs.. For example, nimodipine, a vasodilator, is insoluble in water and is easily affected by the first pass effect of the liver when taken orally. 0.05 mol / L hydroxypropyl-b-cyclodextrin can increase its solubility by 60 times and reduce its irritation to muscle. Injection grade 2-Hydroxypropyl-β-cyclodextrin can also relieve the injection pain caused by etomidate.            


Specification

Please find attached TDS.

 

Package:

Normal package:10kg/fiber drum

 

Storage:

Preserve in well-closed containers,Store at room temperature.


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