Views: 0 Author: Site Editor Publish Time: 2022-05-09 Origin: Site
Hydroxypropyl betadex molecules can change the state and stability of guest molecules. Cyclodextrin inclusion technology can improve the solubility of poorly soluble drugs, improve bioavailability, enhance drug stability, and reduce drug side effects. , attracting more and more attention
Florfenicol is a broad-spectrum antibiotic dedicated to animals, and has been used in many countries for the prevention and treatment of bacterial diseases in animals such as pigs, cattle, fish and poultry. Due to the poor water solubility of florfenicol, the commonly used clinical preparations are mainly non-water-soluble premixes, the absorption and bioavailability of the drug in animals are very low, the cost of medication is increased, and it is inconvenient to use. In the disease prevention and treatment of large-scale farms, drinking water administration is an important way of group medicine, especially for sick animals with loss of appetite or extinction after the disease. Studies have shown that the use of beta-cyclodextrin inclusion technology can significantly improve the water solubility of florfenicol and improve its bioavailability, which has important clinical value.