How is the toxicity of hydroxypropyl betadex cyclodextrin?
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How is the toxicity of hydroxypropyl betadex cyclodextrin?

Views:0     Author:Site Editor     Publish Time: 2021-04-04      Origin:Site

Technical grade hydroxypropyl betadex cyclodextrin is more and more commonly used in the cosmetics and food industries. Some important active substances are very sensitive to air, temperature and light, such as lipophilic vitamin series. Hydroxypropyl betadex cyclodextrin powder is an effective means to prevent their volatilization. However, due to the nephrotoxicity of its raw material β-CD, some people are concerned about the toxicity of high-purity hydroxypropyl betadex cyclodextrin.


Here is the content list:

  • What are differences between hydroxypropyl betadex cyclodextrin and β-CD?

  • Is hydroxypropyl betadex cyclodextrin toxic to the organism?

  • How does hydroxypropyl betadex cyclodextrin work in cosmetics?


What are differences between hydroxypropyl betadex cyclodextrin and β-CD?

Hydroxypropyl betadex cyclodextrin is a derivative produced by hydroxypropyl substitution at the C2, C3 and C8 positions of β-CD. Due to different reaction conditions, the position of hydroxypropyl substitution is different, so different compounds can be formed.

After the hydroxyl group in β-CD is replaced by a propyl group, the generated hydroxypropyl betadex cyclodextrin molecule is not reductive, stable in alkaline medium, can be decomposed by strong acid, has molecular enveloping effect, and is non-toxic to humans.

These are the same features as β-CD, and the differences between them are as follows

1.        HPBCD has high water solubility at room temperature, generally exceeding 50%, so it cannot crystallize in alcoholic water solution.

2.        The selectivity of the two to the enveloped substances is different, and the ratio of the molecules enveloped by some substances may be changed.

3.        HPBCD is basically not catabolized or accumulated in the human body. Most of the oral grade HPBCD is excreted in the stool. If it is administered parenterally, almost all of it is excreted in urine.

4.        It can promote the rapid release of enveloped substances in the organism.

5.        Compared with other derivatives, such as methyl beta cyclodextrin, it has lower surface activity and lower hemolytic activity, making it safer to use.


Is hydroxypropyl betadex cyclodextrin toxic to the organism?

In terms of safety, according to related subacute and chronic toxicity studies, hydroxypropyl betadex cyclodextrin will not cause disease in mice, nor will it cause death.

After intravenous injection in rabbits, hydroxypropyl betadex cyclodextrin was quickly eliminated from the blood and was eliminated from the body with urine. Even continuous injection showed no adverse symptoms as well. The intravenous administration cyclodextrin of 200 mg/Kg to mice and monkeys showed no clinical side effects.

Most importantly, human clinical studies have shown that oral, intravenous infusion, intravenous injection, nasal, sublingual and ocular administration of hydroxypropyl betadex cyclodextrin showed no adverse reactions.

In addition, the irritation of hydroxypropyl betadex cyclodextrin to the skin, eyes and muscles is also close to zero. This shows that HP-β-CD is very safe to organisms.


How does hydroxypropyl betadex cyclodextrin work in cosmetics?

With the progress of society, the development of economic conditions and the improvement of people's living standards, the cosmetics industry has received more and more attention, and people's requirements for cosmetics have become higher and higher.

The research focus of cosmetics has changed from a single improvement of human appearance and odor to a modification of the exterior with meeting safety and health requirements. In this field, the technical process of hydroxypropyl betadex cyclodextrin has been quite mature.

As we all know, hydroxypropyl betadex cyclodextrin has the ability to adsorb and control organic molecules. This function has attracted the attention of the cosmetics industry in many industrial fields.

Cosmetic manufacturers use anti-aging active ingredients to prevent skin aging, such as vitamin A, vitamin E and vitamin F, as well as tea tree oil extracted from the leaves of a plant to cosmetics.

Although these anti-aging ingredients are very effective, they are sensitive to ultraviolet light, heat and atmospheric oxidation and are easily damaged. Therefore, effective protection must be carried out to extend the shelf life of cosmetics.

However, this process not only cannot destroy the active ingredients, but also cannot produce by-products harmful to the human body. Coupled with the comprehensive consideration of cost, hydroxypropyl betadex cyclodextrin has become the most cost-effective choice.

In the fragrance, household daily necessities, pharmaceutical and cosmetic industries, hydroxypropyl betadex cyclodextrin complex can be used as an intermediary to improve the performance of active ingredients.


Now, the microencapsulation process of cosmetic grade hydroxypropyl betadex cyclodextrin is very mature, and it is widely used in cosmetics and food products that directly contact the human body. Shandong Binzhou Zhiyuan Biotechnology Co., Ltd. produces high-purity hydroxypropyl betadex cyclodextrin, and our products are certified by authoritative organizations. By choosing our HPBCD inclusion complex, your product quality is guaranteed.




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