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How is betadex sulfobutyl ether sodium used in the pharmaceutical industry?
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How is betadex sulfobutyl ether sodium used in the pharmaceutical industry?

Views:0     Author:Site Editor     Publish Time: 2021-10-13      Origin:Site

Betadex sulfobutyl ether sodium is a product in which the partial structure of β-cyclodextrin, a derivative of cyclodextrin, is replaced by sulfobutyl. In this article, based on the application of cyclodextrin, we will show in detail the application of betadex sulfobutyl ether sodium in the field of analytical medicine. So that customers have a more comprehensive understanding of our products, and can use this as a basis when choosing products and services, to better meet their own needs.

Here is the content list:

What characteristics of betadex sulfobutyl ether sodium allow it to be used in medicine?

How does betadex sulfobutyl ether sodium play its role in the field of medicine?


What characteristics of betadex sulfobutyl ether sodium allow it to be used in medicine?

Betadex sulfobutyl ether sodium is an anionic, highly water-soluble cyclodextrin derivative. Betadex sulfobutyl ether sodium has special affinity and inclusion properties for nitrogen-containing drugs, and can be well included with drug molecules to form non-covalent complexes to improve drug stability, water-solubility, safety, and reduce nephrotoxicity. Alleviate the hemolysis of the drug, control the release rate of the drug, and cover up bad odors.


How does betadex sulfobutyl ether sodium play its role in the field of medicine?

Betadex sulfobutyl ether sodium can effectively increase the solubility and dissolution rate of some poorly water-soluble drugs in water. For example, the prostaglandin-CD inclusion compound can increase the solubility of the main drug to make injections. Betadex sulfobutyl ether sodium can also improve the stability and bioavailability of drugs, such as Changkang granules volatile oil. Not only that, some drugs with an unpleasant or bitter taste, such as Andrographis paniculata, can also use betadex sulfobutyl ether sodium to mask its odor, making it more acceptable to patients. Reducing the irritation and side effects of drugs, such as diclofenac sodium, and making the dosage form of drugs, such as berberine hydrochloride, be released and improved are also specific roles played by betadex sulfobutyl ether sodium in the field of medicine.

Because betadex sulfobutyl ether sodium is composed of glucose, it has the characteristics of non-toxic, harmless, no side effects, and can be absorbed by the human body. Betadex sulfobutyl ether sodium is widely used as a filler and binder for drugs and has the general properties of starch. The truncated cone-shaped cavity of betadex sulfobutyl ether sodium can envelop various guest molecules. It is being used as a slow-release agent of drugs to envelop the effective ingredients of the drug in the cavity, allowing the drug to slowly Released to improve the efficacy of the medicine. The enveloping effect of betadex sulfobutyl ether sodium can also stabilize some drugs and prolong the validity period of the drugs. The clathrate prepared is easy to powder, can be made into powders, tablets, and is also easy to store, forming a better dosage form. The application of betadex sulfobutyl ether sodium in the pharmaceutical industry has broad and attractive prospects.


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