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How is betadex sulfobutyl ether sodium made?
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How is betadex sulfobutyl ether sodium made?

Views:0     Author:Site Editor     Publish Time: 2021-10-11      Origin:Site

In this article, we will introduce the production of betadex sulfobutyl ether sodium. We will explain the raw materials needed to make the betadex sulfobutyl ether sodium and the physical and chemical operations during the preparation of the betadex sulfobutyl ether sodium. So that customers have a more comprehensive understanding of betadex sulfobutyl ether sodium, and provide more complete information for purchasing products.


Here is the content list:

What is the general process of making betadex sulfobutyl ether sodium?

What are the raw materials for making betadex sulfobutyl ether sodium?


What are the raw materials for making betadex sulfobutyl ether sodium?

Betadex sulfobutyl ether sodium is a derivative of β-cyclodextrin. Betadex sulfobutyl ether sodium is the sodium salt of beta-cyclodextrin that is alkylated by 1,4-butane sultone under alkaline conditions. It is an anionic, highly water-soluble beta-cyclodextrin derivative. Because β-cyclodextrin 6 (including 2 and 3) OH is replaced by sulfobutyl (CH2)4SO3H, betadex sulfobutyl ether sodium is formed. Through this description of how β-cyclodextrin molecules are transformed into betadex sulfobutyl ether sodium molecules, it is not difficult to see that the main raw material for making betadex sulfobutyl ether sodium is β-cyclodextrin and 1,4-sulfobutyrolactone.


What is the general process of making betadex sulfobutyl ether sodium?

When making betadex sulfobutyl ether sodium, we will first introduce an appropriate amount of organic solvent into the alkaline aqueous solution. The reason for this is to increase the solubility of 1,4-sulfobutyrolactone, so that the content of 1,4-sulfobutyrolactone in the unit solution is higher, thereby improving the efficiency of the reaction, and ultimately increasing the synthetic yield. In other words, it means to produce more betadex sulfobutyl ether sodium per unit time and produce betadex sulfobutyl ether sodium with better quality.

After the above process, the chemical conversion of β-cyclodextrin and 1,4-sulfobutyrolactone to betadex sulfobutyl ether sodium ends. But we have not produced the final finished product. The preliminary chemical preparation of the betadex sulfobutyl ether sodium solution also requires ultrasonic dialysis to separate the solute and solvent in the solution. Then we will get the solute, namely betadex sulfobutyl ether sodium, to decolorize with activated carbon. This step is not only to make the finished product more beautiful but also to reduce the interference of the color on the observation work of the operator when used as an auxiliary material. The betadex sulfobutyl ether sodium separated from the solvent will still retain a little water. To facilitate storage and reduce the incidence of product deterioration, we will take the damp betadex sulfobutyl ether sodium to freeze-dry, and reduce its water content without affecting its efficacy.

A series of operations will be carried out afterwards, but the above is the main preparation process. After going through a set of procedures, we can finally gain the betadex sulfobutyl ether sodium sold in our company today. Our company strictly abides by the requirements of each process when making betadex sulfobutyl ether sodium, and is committed to providing customers with high-quality products at all times.


If you are interested in our products, please consult the official website: https://www.cycdextrin.com/. Thank you very much for your support.


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