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How can pharm grade hydroxypropyl betadex be made?
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How can pharm grade hydroxypropyl betadex be made?

Views:0     Author:Site Editor     Publish Time: 2021-06-26      Origin:Site

In the fields of catalysis, separation, food and medicine, hydroxypropyl betadex has received great attention and are widely used. Every year, the global market size of pharm grade hydroxypropyl betadex is increasing, and its output reaches unimaginable numbers. Therefore, the preparation of white pharm grade hydroxypropyl betadex powder requires scientific and efficient methods.


Here is the content list:

  • Can pharm grade cyclodextrins form stable inclusion compound?

  • How to produce pharm grade cyclodextrins inclusion compound?

  • What is the status of pharm grade cyclodextrins in the medical field?


Can pharm grade cyclodextrins form stable inclusion compound?

The outer edge is hydrophilic, and the inner cavity is hydrophobic, and it can be incorporated with a variety of objects. Pharm grade CD is the general term for a series of cyclic oligosaccharides, which are produced by amylose under the action of cyclodextrin glucosyltransferase produced by Bacillus.

Inclusion compound of pharm grade hydroxypropyl betadex is formed by enclosing all or part of a molecule's spatial structure with another molecule, also known as molecular capsule. 

Whether the inclusion compound can be formed and whether it is stable depends mainly on the three-dimensional structure of the host molecule and the guest molecule and the polarity of the two. It is a physical process rather than a chemical reaction. 

The inclusion medical grade cyclodextrins compound prepared by a proper method can greatly improve some properties of the guest.


How to produce pharm grade cyclodextrins inclusion compound?

One of the earliest application areas of CD is the pharmaceutical industry. The use of pharm grade hydroxypropyl betadex to form an inclusion compound with the drug can stabilize, slow-release, emulsify, improve solubility and dispersion and other functions, thereby improving the characteristics of the drug.

The manufacturing methods of pharm grade hydroxypropyl betadex are varied, and each manufacturer has different formulations and production equipment. Therefore, a few general methods are briefly listed below for reference:

Saturated aqueous

This method refers to adding the guest substance to a saturated aqueous solution of pharm grade hydroxypropyl betadex, stirring for a period of time at a certain temperature, and filtering and drying after cooling and crystallizing.

Ultrasound

Add the guest substance to the saturated aqueous solution of pharm grade hydroxypropyl betadex, use an ultrasonic breaker or a washing machine, select the appropriate ultrasonic intensity and time, and treat the precipitate according to the above method. This method is simple and quick.

Grinding method

Mix pharm grade cyclodextrins with a quantitative solid drug, and grind in a ball mill for a certain period of time to obtain the finished product. 

However, this method can only be prepared in a small amount, and manual operation is required, which is not suitable for large-scale production. For large-scale industrial production, it can also be prepared by colloid milling.

Freeze-drying

Some drugs are easily soluble in water, and their inclusion compounds are easily decomposed and discolored during the drying process. For this product, generally use freeze-drying method. 

The finished product of this method has good porosity and solubility, and can reach injection grade. In addition, the pharm grade cyclodextrins inclusion compound prepared by this method can increase the solubility of the drug and improve the bioavailability.


What is the status of pharm grade cyclodextrins in the medical field?

The discovery of pharm grade cyclodextrins has been more than one hundred years, but in the early stage, due to the poor stability of the cyclodextrin generating enzyme, low yield, and toxicity of the organic precipitant added during separation and purification, the research and application of cyclodextrin were restricted.

It was not until the middle of 1970s that the production of pharm grade cyclodextrins on a certain scale was realized after solving the two major problems of yield and toxicity.

Nowadays, pharm grade hydroxypropyl betadex can prevent the oxidation and decomposition of the drug, improve the solubility. pharm grade hydroxypropyl betadex can also reduce the toxicity and side effects of the drug, and mask the peculiar odor of the drug. 

It can be seen that the application of pharm grade hydroxypropyl betadex in modern pharmaceutical preparation technology has an irreplaceable role.

In the future, the application of pharm grade cyclodextrins will surely bring greater development to the pharmaceutical industry. It is particularly worth mentioning that as the main body of enzyme model and self-assembly and molecular recognition, pharm grade hydroxypropyl betadex will have immeasurable development prospects.


For a long time, pharm grade cyclodextrins crystalline inclusion compound has been a hot topic for research in the industry. Shandong Binzhou Zhiyuan Biotechnology Co., Ltd. is a high-tech injection grade hydroxypropyl betadex production company. We provide you with various graded products. If you are looking for white hydroxypropyl betadex powder suitable for the medical field, you can consult our customer service.


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