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Dual effects of hydroxypropyl betadex in enrofloxacin soluble powder as solubilization aid and taste masking
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Dual effects of hydroxypropyl betadex in enrofloxacin soluble powder as solubilization aid and taste masking

Views: 0     Author: Site Editor     Publish Time: 2022-09-20      Origin: Site

Enrofloxacin is a chemically synthesized third-generation quinolone drug, and it is also a fluoroquinolone drug specially used for livestock and poultry. The technical challenge of enrofloxacin soluble powder is masking the bitter taste. In addition, the preparation products have poor disintegration in water and are insoluble in water, so they can only be mixed and fed, and cannot be used for drinking water on poultry animals, resulting in inconvenience in use and waste of drugs, threatening environmental safety.

In view of the above problems, the double taste masking technology of molecular inclusion and spraying sustained-release has a good taste masking effect, which solves the problem of limited clinical use of enrofloxacin with bitter taste. Adding hydroxypropyl betadex to the enrofloxacin powder preparation process can not only solve the problem of water solubility, but also achieve the purpose of masking the taste of the drug through sustained release in the oral cavity of animals, which can avoid ordinary enrofloxacin The phenomenon of conventional coating of granule formulations to mask the taste of one and the other appears, which has great technical advantages.

Shandong Binzhou Zhiyuan Biotechnology Co., Ltd is a high-tech enterprise focusing on the R&D, production and application of hydroxypropyl betadex. It has a complete R&D, quality inspection center and a professional scientific research team. The university and Fudan University maintain a long-term cooperative relationship, and it is a domestic production-oriented enterprise with various types and complete specifications of cyclodextrin.


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