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Can hydroxypropyl beta cyclodextrin be used to make antiviral vaccines?
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Can hydroxypropyl beta cyclodextrin be used to make antiviral vaccines?

Views:0     Author:Site Editor     Publish Time: 2021-05-06      Origin:Site

Different people have different evaluations of vaccines, but one thing is certain. Without the birth of the pharm grade hydroxypropyl beta cyclodextrin vaccine, diseases that cannot be prevented may become a threat to all mankind. As a raw material with high medical value, medical hydroxypropyl beta cyclodextrin has been studied by many experts in recent years. It can be said that hydroxypropyl beta cyclodextrin for vaccine plays a vital role in the development of antiviral vaccines.

 

Here is the content list:

  • Is the application field of hydroxypropyl beta cyclodextrin extensive?

  • What is the antiviral test result of hydroxypropyl beta cyclodextrin?

  • What is the role of hydroxypropyl beta cyclodextrin in antiviral vaccines?

 

Is the application field of hydroxypropyl beta cyclodextrin extensive?

CD was first discovered in the starch digestive juice of Amylobacter as early as 1891. Structural analysis proved that cyclodextrin is formed by linking 6-12 D-glucopyranose. It has a three-dimensional ring structure with a slightly cone-shaped hollow cylinder. Among all the derivatives, hydroxypropyl beta cyclodextrin is the most promising one.

Because hydroxypropyl beta cyclodextrin has the characteristics of "hydrophobic inside and hydrophilic outside", its cavities can contain various guests, such as organic molecules, inorganic ions, complexes and inert gases.

They form clathrates through weak interactions to change the physical and chemical properties and biological properties of the guest molecules. Therefore, hydroxypropyl beta cyclodextrin is widely used in medicine, food, dyes, cosmetics, catalysis, industry, agriculture, national defense and other fields.

In the hotspots of the 21st century, such as life sciences, materials science, energy science, environmental science, information science, nanoscience, molecular machines, molecular devices, enzyme simulation, molecular recognition, chiral separation, drug carriers, catalysis science. Hydroxypropyl beta cyclodextrin also shows broad application prospects.

Not only that, but the application of hydroxypropyl beta cyclodextrin in many natural science fields such as chemistry, biochemistry, biophysics, and bionics is also obvious to all. It can be said that hydroxypropyl beta cyclodextrin is a new type of science.

 

What is the antiviral test result of hydroxypropyl beta cyclodextrin?

According to related studies, from the published in vitro virus inhibition data, the modified hydroxypropyl beta cyclodextrin is about 3 times more active than CD. From the virus killing test, the effect of hydroxypropyl beta cyclodextrin is also very obvious.

The sugar chains on the cell surface are the contact points of bacteria, viruses, and immune cells. Broad-spectrum antiviral drugs, such as heparin or heparinoid materials, have been developed to mimic cell surface sugars responsible for the initial virus attachment, such as heparan sulfate.

However, due to unknown clearance mechanisms and potential long-term toxicity, some active ingredient particles are problematic as drugs. Hydroxypropyl beta cyclodextrin is a natural glucose derivative with a rigid ring structure composed of α(1-4) linked glucopyranose.

Hydroxypropyl beta cyclodextrin is used in many commercial applications, including drug delivery, air fresheners, cosmetics, and food.

The modified hydroxypropyl beta cyclodextrin molecule can destroy the outer shell of the virus, thereby destroying them upon contact. This method has also been shown to be effective against resistant viruses.

 

What is the role of hydroxypropyl beta cyclodextrin in antiviral vaccines?

Past studies have described the most commonly studied application of hydroxypropyl beta cyclodextrin, the solubilization and stabilization of antiviral drugs; some examples also involve its ability to mask odors.

Now, scientists have discovered the role of hydroxypropyl beta cyclodextrin in the development and stabilization of antiviral vaccines, in which they are used as adjuvants and cryogens.

  • A polymer based on hydroxypropyl beta cyclodextrin as an mRNA delivery system is currently under development.

  • The scientists also used hydroxypropyl beta cyclodextrin as a drug to explore the active ingredients used to treat viral infections. This new application area is still taking the first step.

  • The encouraging results of using hydroxypropyl beta cyclodextrin as a drug to treat other diseases are encouraging. We can understand that the recently approved HIV vaccine contains HPβCD as a cryopreservation agent in its formulation, that is, to avoid cold-induced surface damage to the virus particles.

 

Although we do not sell finished hydroxypropyl beta cyclodextrin for vaccines, we provide high-purity raw materials. We have been committed to the production and research of hydroxypropyl beta cyclodextrin powder, and has in-depth cooperation with many scientific research institutions. Shandong Binzhou Zhiyuan Biotechnology Co., Ltd. is willing to explore the wide application of injection grade hydroxypropyl beta cyclodextrin in the field of vaccines together with our colleagues.


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