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Application of sulfobutyl beta cyclodextrin sodium in dezocine powder injection
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Application of sulfobutyl beta cyclodextrin sodium in dezocine powder injection

Views:0     Author:Site Editor     Publish Time: 2021-05-06      Origin:Site

The marketed product dezocine injection, its raw material is easy to oxidize when placed in an aqueous solution for a long time, and its auxiliary material is added sodium metabisulfite as an antioxidant. Sulfate may cause fatal allergic reactions and severe asthma for some susceptible people. If there is a drug-carrying system characterized in that the carrier used in the drug-carrying system has a biocompatible and biodegradable polymer carrier material, the problem of side effects can be solved. For example: Dezocine and sulfobutyl beta cyclodextrin sodium (SBECD) inclusion compound solution, concentrated under reduced pressure, filtered, filled, sealed, and sterilized to make injections; or combine dezocine and sulfonbutane The solution of SBECD inclusion compound is filtered, and the obtained solution is subjected to "vacuum drying", "spray drying" or "freeze drying" to obtain a white powder, which is made into a powder injection. It is a good polymer carrier material combined with drugs to reduce side effects and increase bioavailability.


SBECD, BETADEX SULFOBUTYL ETHER SODIUM

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