+86-531-88916568
Application of Methyl beta cyclodextrin (MEBCD, CAS 128446-36-6) in chemistry, chemical industry and medicine
Home » News » Application of Methyl beta cyclodextrin (MEBCD, CAS 128446-36-6) in chemistry, chemical industry and medicine

Application of Methyl beta cyclodextrin (MEBCD, CAS 128446-36-6) in chemistry, chemical industry and medicine

Views:0     Author:Site Editor     Publish Time: 2021-01-18      Origin:Site

Methyl-β-cyclodextrin (Me-β-CD, MEBCD) is an alkylated derivative of β-cyclodextrin (β-CD). Since Me-β-CD is not only water soluble but also soluble in organic solvents, it has a strong ability to include drugs, so it is a relatively important product, and the pharmaceutical preparation industry pays great attention to it. But because it has a strong hemolytic effect, its application casts a shadow. However, in recent years, its use for the solubilization of oral drugs, suppositories, transdermal absorbers, nasal sprays and other small doses of insoluble drugs has become a hot spot.

20210118 (1)

Methyl-β-cyclodextrin (Me-β-CD, MEBCD) is known as the most effective cosolvent for insoluble substances and the best stabilizer for many chemical substances among the known cyclodextrin derivatives. Because Me-β-CD has excellent solubility and inclusion functions, and because it is soluble in water and organic solvents, it is widely used in medicine, food, pesticides, cosmetics, daily chemicals, and chemical industries. , Textile dyeing and finishing, chromatographic analysis and functional materials.

Methyl-β-cyclodextrin (Me-β-CD, MEBCD) has better inclusion ability and solubility for drugs. However, its outstanding shortcoming is that it has a strong hemolytic effect. Because Me-β-CD has hemolytic effect and irritation to mucosa, it is not suitable for injection drug application.

However, it is also mentioned in the latest reviews of Me-β-CD that only at higher concentrations, Me-β-CD will damage the cell membrane. At low concentrations, it will not produce any hemolysis and stabilize the cell membrane. Play a protective role. Therefore, for drugs with poor solubility and high activity, Methyl-β-cyclodextrin (Me-β-CD, MEBCD) can be used in some preparations when the dosage is very low.

20210118 (2)


PRODUCT CATEGORY

QUICK LINKS

CONTACT INFORMATION

Tel: +86-531-88916568
 Mail: enquiry@cydextrin.com
​​​​​​​ Address: Boxing Economic Development Zone, Binzhou, Shandong, China.

FREE CONSULTATION

Contact us
© 2020 Shandong Binzhou Zhiyuan Biotechnology Co., Ltd. All rights reserved. Sitemap