Application of Hydroxypropyl-β-Cyclodextrin in New Houttuyfonate Sodium Injection
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Application of Hydroxypropyl-β-Cyclodextrin in New Houttuyfonate Sodium Injection

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       Neo-Houttuyninum chemical name is lauryl acetaldehyde sodium bisulfite, which is an adduct of lauryl acetaldehyde sodium bisulfite, and is the first effective anti-bacterial and anti-inflammatory drug used in clinical practice in my country. It is clinically used to treat pelvic inflammatory disease, adnexitis, cervicitis, and has good curative effect. The synthesized new houttuyfonate sodium is a white scaly or needle-like or crystalline powder, which is easily soluble in hot water and slightly soluble in water and ethanol. Since the raw materials are slightly soluble in water, in order to make injections, a large amount of Tween-80 must be added to the prescription. Tween-80 is a non-ionic surfactant, which is not only prone to hemolysis, but also has certain toxicity, which is not in line with modern times. Pharmaceutical preparation requirements. In addition, when the injection is injected intramuscularly, pain occurs, and the patient has fear during use; at the same time, crystals are easy to precipitate during storage.

       New Houttuyfonate Sodium Injections include: New Houttuyfonate Sodium Injection, New Houttuyfonate Sodium Lyophilized Powder Injection, New Houttuyfonate Sodium Sterile Powder Injection, New Houttuyfonate Sodium Glucose Injection, New Houttuyfonate Sodium and Sodium Chloride Injection.

       Hydroxypropyl-β-cyclodextrin is a derivative of β-cyclodextrin, its water solubility is extremely high, it can reach more than 50% at room temperature, and it is non-toxic and non-irritating. The US FDA has approved it as an injection Use accessories.

       The use of hydroxypropyl-β-cyclodextrin dextrin for inclusion and solubilization of the new houttuyfonate not only completely solves the water-soluble problem of the new houttuyfonate, but also increases the drug content per unit volume and reduces the cost , And can improve the safety and stability of the drug, and reduce irritation.

hydroxypropyl beta cyclodextrin




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