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Carfentanyl is a derivative of fentanyl, which has a significant analgesic effect but poor water solubility. Carfentanil-containing dimethyl-β-cyclodextrin (DM-β-CD) inclusion compound and its nasal spray were prepared by ultrasonic method, which can increase the solubility of carfentanil. Th
Cyclodextrin (CD) is a type of cyclic oligosaccharide produced by the interaction of starch and cyclodextrin glucosyltransferase (CGT). Its structure is characterized by a slightly cone-shaped ring with a hydroxyl group on the outside of the molecule. It aggregates and is hydrophilic. There are two
Methyl-β-cyclodextrin is widely used to increase the permeability of cells, thereby increasing the absorption of small molecules such as glucose and nanoparticles. Cyclodextrins are a family of cyclic oligosaccharides with a hydrophilic outer surface and a lipophilic central cavity. Cyc
Cyclodextrin (CD) is a kind of cyclic polysaccharide connected by α-1,4-glycosidic bonds. The cyclodextrin family mainly includes α-cyclodextrin, β-cyclodextrin, and γ-cyclodextrin, which are composed of 6, 7, and 8 glucose structural units, respectively, arranged in a truncated cone shape. A
